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Article

Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk.

Pediatric blood & cancer - 15 Dec 2009

Dorak M Tevfik, Mackay Rachel K, Relton Caroline L, Worwood Mark, Parker Louise, Hall Andrew G

Abstract excerpt

BACKGROUND: Our original studies reported an association between the iron-metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effect on cell proliferation, iron is involved in both fetal development and cancer. We hypothesize that HFE links higher infant birth weight with leukemia risk and that maternal HFE genotype modifies this...

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Source

Identifiers

PMID: 19711434
DOI: 10.1002/pbc.22236

Genes

HFE
TFRC
HAMP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk.PMID 19711434Read ↗

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HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.Semantic proximity Read ↗

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HFE gene mutation and iron overload in Egyptian pediatric acute lymphoblastic leukemia survivors: a single-center study.Semantic proximity Read ↗

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