Article
Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women.
Maturitas - 20 Oct 2006
Long Ji-Rong, Shu Xiao-Ou, Cai Qiuyin, Cai Hui, Gao Yu-Tang, Jin Fan, Zheng Wei
Abstract excerpt
The Cytochrome P450 1B1 (CYP1B1) is one of the major CYP450 enzymes catalyzing 4-hydroxylation, an important elimination step for estrogens. Relatively little is known, however, about the impact of this gene on the onset and cessation of menstruation, which are significant milestones in a woman's life and predictors of many hormone related diseases. In this report, we described the association of four SNPs in the...
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