Article
Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy.
Novartis Foundation symposium - 1 Jan 2005
Kozlov Serguei, Mounkes Leslie, Cutler Dedra, Sullivan Terry, Hernandez Lidia, Levy Nicolas, Rottman Jeff, Stewart Colin L
Abstract excerpt
At least ten different diseases have been linked to mutations in proteins associated with the nuclear envelope (NE). Eight of these diseases are associated with mutations in the lamin A gene (LMNA). These diseases include the premature ageing or progeric diseases Hutchinson-Gilford progeria and atypical Werner's syndrome, diseases affecting striated and cardiac muscle including muscular dystrophies and dilated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.