Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.

Journal of medicinal chemistry - 24 Mar 2005

Daniels David J, Kulkarni Amol, Xie Zhihua, Bhushan Rashmi G, Portoghese Philip S

Abstract excerpt

To characterize delta- and kappa-opioid receptor phenotypes, bivalent ligands (KDAN series) containing delta-antagonist (naltrindole) and kappa(1)-agonist (ICI-199,441) pharmacophores were synthesized and evaluated by the intrathecal route using the mouse tail-flick assay and binding studies. The data have suggested that KDAN-18 (2) bridges phenotypic delta(2)- and kappa(1)-receptors. A conceptual model is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Amides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding, Competitive

Share to Naltrexone

Share to Pyrrolidines

Share to Radioligand Assay

Share to Receptors, Opioid, delta

Share to Receptors, Opioid, kappa

Source

Identifiers

PMID: 15771416
DOI: 10.1021/jm034234f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.PMID 15771416Read ↗

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.Semantic proximity Read ↗

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches.Semantic proximity Read ↗

Structures of the entire human opioid receptor familySemantic proximity Read ↗

Molecular biology of opioid analgesia.Semantic proximity Read ↗

New vistas in opioid control of pain.Semantic proximity Read ↗

beta-Funaltrexamine, a gauge for the recognition site of wildtype and mutant H297Q mu-opioid receptors.Semantic proximity Read ↗

Opioid receptors.Semantic proximity Read ↗

Molecular determinants underlying DS2 activity at δ-containing GABA <sub>A</sub> receptorsSemantic proximity Read ↗

The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor.Semantic proximity Read ↗

Molecular determinants of NMDA receptor pharmacological diversity.Semantic proximity Read ↗

Chemotype-selective modes of action of κ-opioid receptor agonists.Semantic proximity Read ↗

Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.