Article
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
The Journal of pharmacology and experimental therapeutics - 1 Apr 2005
Tryoen-Tóth P, Décaillot F M, Filliol D, Befort K, Lazarus L H, Schiller P W, Schmidhammer H, Kieffer B L
Abstract excerpt
The delta opioid receptor modulates nociceptive and emotional behaviors. This receptor has been shown to exhibit measurable spontaneous activity. Progress in understanding the biological relevance of this activity has been slow, partly due to limited characterization of compounds with intrinsic negative activity. Here, we have used constitutively active mutant (CAM) delta receptors in two different functional...
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