Article
Mechanisms of the development of androgen independence in prostate cancer.
World journal of urology - 1 Feb 2005
So Alan, Gleave Martin, Hurtado-Col Antonio, Nelson Colleen
Abstract excerpt
The effectiveness of androgen ablation in the management of advanced prostate cancer is of limited duration, with the median length of response being only 18-24 months. The transition of the prostate cancer cell to an androgen independent phenotype is a complex process that involves selection and outgrowth of pre-existing clones of androgen-independent cells (clonal selection) as well as adaptive up-regulation of...
Topics
- Androgens
- Animals
- Antineoplastic Agents
- Apoptosis
- Humans
- Male
- Mutation
- Prostatic Neoplasms
- Proto-Oncogenes
- Receptors, Androgen
- Treatment Outcome