Article
Novel single nucleotide polymorphism of UGT1A9 gene in Japanese.
Drug metabolism and pharmacokinetics - 1 Feb 2006
Fujita Ken-ichi, Ando Yuichi, Nagashima Fumio, Yamamoto Wataru, Endo Hisashi, Kodama Keiji, Araki Kazuhiro, Miya Toshimichi, Narabayashi Masaru, Sasaki Yasutsuna
Abstract excerpt
We sequenced from 5'-franking region to intron 1 (to 337 bp downstream from exon 1) of the UDP-glucuronosyltransferase (UGT) 1A9 gene prepared from 55 Japanese cancer patients. Seven single nucleotide polymorphisms (SNPs) were found. Two of them were UGT1A9 -118(T)n (n=10) and UGT1A9*5, and four were reported SNPs in intron 1 of UGT1A9 gene (89540C>T, 89549G>A, 89616T>A and 89710A>C). A novel SNP (89587T>C) was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.