Article
Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling.
Pharmacogenomics - 1 May 2009
Xing Yi, Yang Lun, Wang Lei, Shao Liyan, Wei Zhiyun, Xuan Jiekun, Li Jun, Qin Shengying, Shu Anli, He Lin, Xing Qinghe
Abstract excerpt
AIMS: To date, there have been relatively few studies on the UGT1A6 gene in the Chinese population. The present study was designed to determine the allele frequencies and haplotypes of this gene in the population and predict the candidate functional mutations. MATERIALS & METHODS: We carried out the first systematic screening of polymorphisms of the gene in an SNP analysis involving 1074 Chinese subjects from...
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