Article
The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes.
Development (Cambridge, England) - 1 Jan 1992
Capovilla M, Eldon E D, Pirrotta V
Abstract excerpt
The sequence of a cDNA from the giant gene of Drosophila shows that its product has a basic domain followed by a leucine zipper motif. Both features contain characteristic conserved elements of the b-ZIP family of DNA-binding proteins. Expression of the gene in bacteria or by in vitro translation yields a protein that migrates considerably faster than the protein extracted from Drosophila embryos. Treatment with...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Western
- DNA-Binding Proteins
- Drosophila
- Gene Expression
- Gene Expression Regulation
- Genes
- Genes, Regulator
- Leucine Zippers