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Article

Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems

1 Jan 2005

Abstract excerpt

Epigenetic control provides a mechanism for the reversible silencing of telomerase expression that occurs as a natural consequence of differentiation. Significant overlap between indirect telomerase regulation pathways and cell cycle checkpoint pathways exist, suggesting that these discrete genetic elements (namely, p21, p53, and hTERT) synergistically cooperate to inhibit tumorigenesis. Mutations in these...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 15769667
DOI: 10.2741/1661

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