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Telomerase in human development and cancer

1 Nov 1997

Abstract excerpt

A potentially rate-limiting step in cancer progression is the conversion of a normal human cell into one capable of indefinite proliferation. There are at least two different cellular mechanisms that must be overcome before immortalization occurs. The first step generally requires inactivation of the pathways involving two tumor-suppressor genes, p53 and pRB, and the second step almost always involves the...

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Identifiers

PMID: 9365534
DOI: 10.1002/(sici)1097-4652(199711)173:2<266::aid-jcp33>3.0.co;2-b

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