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Article

ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.

Molecular and cellular biology - 1 Apr 2005

Gangwani Laxman, Flavell Richard A, Davis Roger J

Abstract excerpt

Mutation of the survival motor neurons 1 (SMN1) gene causes motor neuron apoptosis and represents the major cause of spinal muscular atrophy in humans. Biochemical studies have established that the SMN protein plays an important role in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and that the SMN complex can interact with the zinc finger protein ZPR1. Here we report that targeted ablation of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 15767679
DOI: 10.1128/MCB.25.7.2744-2756.2005
PMCID: PMC1061650

Genes

ZPR1
SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.PMID 15767679Read ↗

Deficiency of the zinc finger protein ZPR1 causes neurodegenerationSemantic proximity Read ↗

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Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy.Semantic proximity Read ↗

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophySemantic proximity Read ↗

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Heterozygous loss of SRRM1 may be associated with neurodevelopmental phenotypes and anomalies in cell growth and neurite morphology.Semantic proximity Read ↗

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryosSemantic proximity Read ↗

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal BodiesSemantic proximity Read ↗

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Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells.Semantic proximity Read ↗

Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies.Semantic proximity Read ↗

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