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Article

Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy.

Scientific reports - 15 Aug 2017

Genabai Naresh K, Kannan Annapoorna, Ahmad Saif, Jiang Xiaoting, Bhatia Kanchan, Gangwani Laxman

Abstract excerpt

Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy. Respiratory failure causes death in SMA but the underlying molecular mechanism is unknown. The zinc finger protein ZPR1 interacts with SMN. ZPR1 is down regulated in SMA patients. We report that ZPR1 functions downstream of SMN to regulate HoxA5...

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Source

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Identifiers

PMID: 28811488
DOI: 10.1038/s41598-017-07603-z
PMCID: PMC5557895

Genes

ZPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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