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Article

Deficiency of the zinc finger protein ZPR1 causes neurodegeneration

28 Apr 2006

Abstract excerpt

Mutations that cause reduced expression of the full-length Survival Motor Neurons (SMN) protein are a major cause of spinal muscular atrophy (SMA), a disease characterized by degeneration of the alpha-motor neurons in the anterior horn of the spinal cord. The severity of SMA may be influenced by the actions of modifier genes. One potential modifier gene is represented by ZPR1, which is down-regulated in patients...

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PMID: 16648254
DOI: 10.1073/pnas.0602057103

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