Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies.

Neuromolecular medicine - 1 Mar 2011

Morse Robert, Todd Adrian G, Shaw Debra J, McConville Alison L, Robinson Iain M, Young Philip J

Abstract excerpt

The childhood disorder spinal muscular atrophy (SMA) is caused by reduced expression of the survival motor neuron (SMN) protein. SMN is a multifunctional protein that has been implicated in the production, processing and transport of RNA and ribonucleoproteins (RNPs). Within the nucleus, SMN is predominantly targeted to Cajal bodies (CB), which are involved in the maturation and processing of several subclasses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Exons
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

Share to Mutation

Share to Peptides

Share to Recombinant Fusion Proteins

Share to SMN Complex Proteins

Source

Identifiers

PMID: 21082361
DOI: 10.1007/s12017-010-8139-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies.PMID 21082361Read ↗

Targeting of SMN to Cajal bodies is mediated by self-association.Semantic proximity Read ↗

Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells.Semantic proximity Read ↗

The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy.Semantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic LocalizationSemantic proximity Read ↗

The survival motor neuron protein in spinal muscular atrophySemantic proximity Read ↗

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy.Semantic proximity Read ↗

A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron proteinSemantic proximity Read ↗

Mitochondrial Dysfunction in Spinal Muscular AtrophySemantic proximity Read ↗

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.