Article
Isopentenyl-diphosphate isomerase is essential for viability of Caenorhabditis elegans.
Molecular genetics and genomics : MGG - 1 Apr 2005
Yochem John, Hall David H, Bell Leslie R, Hedgecock Edward M, Herman Robert K
Abstract excerpt
Homozygosity for a mutation in the idi-1 gene of Caenorhabditis elegans results in paralysis during the first larval stage, followed by an arrest of growth and development late in the first larval stage. Apoptotic corpses, which are apparently the result of normal programmed cell death, persist in the arrested larvae. In genetic mosaics, an additional defect becomes evident upon examination with Nomarski optics:...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Carbon-Carbon Double Bond Isomerases
- Cloning, Molecular
- Cytoplasm
- DNA Primers
- Hemiterpenes
- Lysosomes
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Phenotype
- Sequence Analysis, DNA