Article
Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans.
Molecular biology and evolution - 1 Jun 2005
de Groot Natasja G, Garcia Christian A, Verschoor Ernst J, Doxiadis Gaby G M, Marsh Steven G E, Otting Nel, Bontrop Ronald E
Abstract excerpt
The human major histocompatibility complex class I chain-related (MIC) genes are members of a multicopy family showing similarity to the classical HLA-A, HLA-B, and HLA-C genes. Only the MICA and MICB genes produce functional transcripts. In chimpanzees, however, only one MIC gene is expressed, showing an intermediate character, resulting from a deletion fusing the MICA and MICB gene segments together. The...
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