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Article

Amino acid residues 62 and 193 play the key role in regulating the synergism of substrate binding in oyster arginine kinase.

FEBS letters - 14 Mar 2005

Fujimoto Naka, Tanaka Kumiko, Suzuki Tomohiko

Abstract excerpt

The purpose of this study is to clarify the amino acid residues responsible for the synergism in substrate binding of arginine kinase (AK), a key enzyme in invertebrate energy metabolism. AKs contain a pair of highly conserved amino acids (D62 and R193) that form an ion pair, and replacement of these residues can cause a pronounced loss of activity. Interestingly, in the oyster Crassostrea AK, these residues are...

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Identifiers

PMID: 15757662
DOI: 10.1016/j.febslet.2005.02.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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