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Article

Roles of amino acid residues H66 and D326 in the creatine kinase activity and structural stability.

International journal of biological macromolecules - 1 Feb 2018

Wu Qing-Yun, Wei Fang, Zhu Yuan-Yuan, Tong Yu-Xue, Cao Jiang, Zhou Ping, Li Zhen-Yu, Zeng Ling-Yu, Li Feng, Wang Xiao-Yun, Xu Kai-Lin

Abstract excerpt

Creatine kinase (CK) is a key enzyme for cellular energy metabolism, catalyzing the reversible phosphoryl transfer from phosphocreatine to ADP in vertebrates. CK contains a pair of highly conserved amino acids (H66 and D326) which might play an important role in sustaining the compact structure of CK by linking its N- and C- terminal domains; however the mechanism is still unclear. In this study, spectroscopic,...

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PMID: 28916380
DOI: 10.1016/j.ijbiomac.2017.09.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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