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Article

Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors

9 Mar 2005

Abstract excerpt

BACKGROUND: There has been much research into the use of RNA interference (RNAi) for the treatment of human diseases. Many viruses, including hepatitis B virus (HBV), are susceptible to inhibition by this mechanism. However, for RNAi to be effective therapeutically, a suitable delivery system is required. METHODS: Here we identify an RNAi sequence active against the HBV surface antigen (HBsAg), and demonstrate...

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PMID: 15756649
DOI: 10.1002/jgm.739

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