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Article

Gene Expression Profiling of the Irinotecan Pathway in Colorectal Cancer

1 Mar 2005

Abstract excerpt

The exact mechanism responsible for large variation of response to chemotherapy remains unclear. This study profiled the gene expression for the entire irinotecan pathway to provide insights into individualized cancer therapy. The RNA expressions of 24 irinotecan pathway genes were measured in paired tumor and normal tissues from 52 patients with Dukes' C colorectal cancer using a real-time quantitative reverse...

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PMID: 15756032
DOI: 10.1158/1078-0432.ccr-04-1254

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