Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer

27 Jul 2017

Abstract excerpt

BACKGROUND: Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is SN-38) is one of the significant obstacles in the treatment of advanced colorectal cancer (CRC). The molecular mechanism or targets mediating irinotecan resistance are still unclear. It is urgent to find the irinotecan response biomarkers to improve CRC patients' therapy. METHODS: Genetic Omnibus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Colorectal Cancer Treatments and Studies
Share to Fibroblast Growth Factor Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28749961
DOI: 10.1371/journal.pone.0180616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancerPMID 28749961Read ↗

Irinotecan Resistance – In Search of New Markers in CRC.Semantic proximity Read ↗

Integrated Bioinformatics Analysis of the Hub Genes Involved in Irinotecan Resistance in Colorectal CancerSemantic proximity Read ↗

Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysisSemantic proximity Read ↗

Identification of Genes Related to 5-Fluorouracil Based Chemotherapy for Colorectal CancerSemantic proximity Read ↗

Gene signatures associated with drug resistance to irinotecan and oxaliplatin predict a poor prognosis in patients with colorectal cancerSemantic proximity Read ↗

Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal CancerSemantic proximity Read ↗

TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approachSemantic proximity Read ↗

Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agentsSemantic proximity Read ↗

Gene Expression Profiling of the Irinotecan Pathway in Colorectal CancerSemantic proximity Read ↗

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapiesSemantic proximity Read ↗

Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patientsSemantic proximity Read ↗

Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.