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Article

Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.

British journal of haematology - 1 Mar 2005

Hasegawa Daisuke, Manabe Atsushi, Kubota Takeo, Kawasaki Hirohide, Hirose Imiko, Ohtsuka Yoshitoshi, Tsuruta Toshihisa, Ebihara Yasuhiro, Goto Yu-ichi, Zhao Xiao Yan, Sakashita Kazuo, Koike Kenichi, Isomura Mariko, Kojima Seiji, Hoshika Akinori, Tsuji Kohichiro, Nakahata Tatsutoshi

Abstract excerpt

Aberrant DNA methylation is frequently observed in adults with myelodysplastic syndrome (MDS), and is recognized as a critical event in the disease's pathogenesis and progression. This is the first report to investigate the methylation status of p15 and p16, cell cycle regulatory genes, in children with MDS (n = 9) and juvenile myelomonocytic leukaemia (JMML; n = 18) by using a methylation-specific polymerase...

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Share to Cyclin-Dependent Kinase Inhibitor p15
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Chronic

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

Identifiers

PMID: 15755284
DOI: 10.1111/j.1365-2141.2005.05392.x

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.PMID 15755284Read ↗

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