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Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications

1 May 2000

Abstract excerpt

We used a sensitive, quantitative bisulfite PCR assay, methylation sensitive single nucleotide primer extension (Ms-SNuPE), to measure methylation of the 5' CpG islands of c-abl and p15 in chronic myelogenous leukemia (CML) patients during progression. We found that the Pa promoter of c-abl was methylated in 81% (17/21) of the white blood cells (WBCs) of CML patients, which correlates with previous reports. In...

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PMID: 10779450
DOI: 10.1182/blood.v95.9.2990.009k08_2990_2992

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