Article
PEA3, AP-1, and a unique repetitive sequence all are involved in transcriptional regulation of the breast cancer-associated gene, mammaglobin.
Breast cancer research and treatment - 1 Feb 2005
Hesselbrock Diane R, Kurpios Natasza, Hassell John A, Watson Mark A, Fleming Timothy P
Abstract excerpt
The breast cancer-associated gene mammaglobin is a member of the secretoglobin protein family and has demonstrated its utility as a breast cancer marker. However, the transcriptional regulation of mammaglobin has not been well-characterized. In this report, we used luciferase reporter assays to identify the 200 bp directly 5' of the transcriptional start site as the minimal promoter region of mammaglobin....
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