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Article

Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression

4 Dec 2003

Abstract excerpt

The PEA3/E1AF/ETV4 gene encodes an Ets-related transcription factor that is expressed in the epithelial cells of the mammary gland. Previous reports have shown that PEA3 can up-regulate promoter activities of many genes associated with tumorigenesis. A significant fraction of those encode matrix metalloproteinases (MMP genes) required for degradation of the extracellular matrix. To better obtain a molecular...

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PMID: 14633660
DOI: 10.1093/carcin/bgh024

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Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expressionPMID 14633660Read ↗

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The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members.Semantic proximity Read ↗

LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.Semantic proximity Read ↗

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