Article
Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones.
British journal of haematology - 1 Mar 2009
Beer Philip A, Jones Amy V, Bench Anthony J, Goday-Fernandez Andrea, Boyd Elaine M, Vaghela Krishna J, Erber Wendy N, Odeh Bassam, Wright Christine, McMullin Mary Frances, Cullis Jonathan, Huntly Brian J P, Harrison Claire N, Cross Nicholas C P, Green Anthony R
Abstract excerpt
This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones...
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