Article
Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements.
American journal of hematology - 1 Sept 1990
Tohda S, Morio T, Suzuki T, Nagata K, Kamiyama T, Imai Y, Nara N, Aoki N
Abstract excerpt
A patient with two populations of B cell malignancy in the bone marrow is reported. One population consisted of mature small lymphocytes, expressing surface IgM + D, lambda and proliferating very slowly. The other population consisted of abnormal large lymphoid cells, expressing surface IgM, K and proliferating actively. We considered the former as chronic lymphocytic leukemia cells and the latter as malignant...
Topics
- Aged
- Cell Cycle
- Clone Cells
- Female
- Gene Rearrangement, B-Lymphocyte
- Humans
- Immunoglobulins
- Immunologic Techniques
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytes
- Lymphoma