Article
Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis.
Tissue antigens - 1 Sept 2007
Spagnolo P, Sato H, Grutters J C, Renzoni E A, Marshall S E, Ruven H J T, Wells A U, Tzouvelekis A, van Moorsel C H M, van den Bosch J M M, du Bois R M, Welsh K I
Abstract excerpt
Sarcoidosis is a heterogeneous disorder, both phenotypically and genetically. Two independent studies have recently shown that a functional polymorphism within butyrophilin-like 2 (BTNL2) gene predisposes to sarcoidosis independently of the human leukocyte antigen (HLA)-DRB1 alleles. However, in both studies, data analysis was not stratified by Löfgren's syndrome, a clinically and genetically distinct sarcoidosis...
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