Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2005

Weitkamp Jörn-Hendrik, Kallewaard Nicole L, Bowen Amber L, Lafleur Bonnie J, Greenberg Harry B, Crowe James E

Abstract excerpt

Memory B cells expressing the intestinal homing marker alpha4beta7 are important for protective immunity against human rotavirus (RV). It is not known whether the B cell repertoire of intestinal homing B cells differs from B cells of the systemic compartment. In this study, we analyzed the RV-specific VH and VL repertoire in human IgD- B cells expressing the intestinal homing marker alpha4beta7. The mean...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Donors
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin D

Share to Immunologic Memory

Share to Integrins

Share to Intestines

Share to Rotavirus

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 15749880
DOI: 10.4049/jimmunol.174.6.3454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7.PMID 15749880Read ↗

Immunodominance of the VH1–46 Antibody Gene Segment in the Primary Repertoire of Human Rotavirus-Specific B Cells Is Reduced in the Memory Compartment through Somatic Mutation of Nondominant ClonesSemantic proximity Read ↗

Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells.Semantic proximity Read ↗

Infant and Adult Human B Cell Responses to Rotavirus Share Common Immunodominant Variable Gene RepertoiresSemantic proximity Read ↗

Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal MucosaSemantic proximity Read ↗

Characteristics of IgVH genes used by human intestinal plasma cells from childhood.Semantic proximity Read ↗

Functional Maturation of the Human Antibody Response to RotavirusSemantic proximity Read ↗

Distribution and phenotype of rotavirus-specific B cells induced during the antigen-driven primary response to 2/6 virus-like particles administered by the intrarectal and the intranasal routes.Semantic proximity Read ↗

Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.Semantic proximity Read ↗

IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated.Semantic proximity Read ↗

Human rotavirus-specific IgM Memory B cells have differential cloning efficiencies and switch capacities and play a role in antiviral immunity in vivo.Semantic proximity Read ↗

Distribution and phenotype of murine rotavirus-specific B cells induced by intranasal immunization with 2/6 virus-like particles.Semantic proximity Read ↗

T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.