Article
Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications.
Swiss medical weekly - 6 Oct 2001
Truninger K, Ammann R W, Blum H E, Witt H
Abstract excerpt
The recent genetic discoveries in CP support the hypothesis that inappropriate intrapancreatic activation of zymogens by trypsin results in autodigestion and pancreatitis. Two different protective mechanisms prevent activation of the pancreatic digestive enzyme cascade. First, SPINK1 inhibits up to 20% of potential trypsin activity and, second, trypsin itself activates trypsin-like enzymes readily degrading...
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