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Article

Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2005

Suk Rebecca, Gurubhagavatula Sarada, Park Sohee, Zhou Wei, Su Li, Lynch Thomas J, Wain John C, Neuberg Donna, Liu Geoffrey, Christiani David C

Abstract excerpt

PURPOSE: ERCC1 is a lead enzyme in the nucleotide excision repair pathway of DNA repair. Polymorphisms have been identified in the ERCC1 gene, the C8092A and codon 118 polymorphisms, which may lead to an altered capacity to regenerate damaged normal tissue and greater treatment-related toxicity. EXPERIMENTAL DESIGN: Using logistic regression models, we evaluated the ERCC1 C8092A and codon 118 polymorphisms and...

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Identifiers

PMID: 15746057
DOI: 10.1158/1078-0432.CCR-04-1953

Genes

ERCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients.PMID 15746057Read ↗

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