Article
[Association between polymorphisms of ERCC1 and response in patients with advanced non-small cell lung cancer receiving cisplatin-based chemotherapy].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Apr 2010
Wang Jinghui, Zhang Quan, Zhang Hui, Wang Qunhui, Yang Xinjie, Gu Yanfei, Zhang Shucai
Abstract excerpt
BACKGROUND AND OBJECTIVE: Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting. The aim of this study is to prospectively assess the association between single nucleotide polymorphisms of C8092A and codon118 in ERCC1 and drug response in 90 patients with...
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