Article
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.
Molecular and cellular biology - 1 Mar 2005
Tadano Makoto, Edamatsu Hironori, Minamisawa Susumu, Yokoyama Utako, Ishikawa Yoshihiro, Suzuki Noboru, Saito Hiromitsu, Wu Dongmei, Masago-Toda Misa, Yamawaki-Kataoka Yuriko, Setsu Tomiyoshi, Terashima Toshio, Maeda Sakan, Satoh Takaya, Kataoka Tohru
Abstract excerpt
Phospholipase Cepsilon is a novel class of phosphoinositide-specific phospholipase C, identified as a downstream effector of Ras and Rap small GTPases. We report here the first genetic analysis of its physiological function with mice whose phospholipase Cepsilon is catalytically inactivated by gene targeting. The hearts of mice homozygous for the targeted allele develop congenital malformations of both the aortic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.