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Article

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.

Nature genetics - 1 Mar 2000

Chen B, Bronson R T, Klaman L D, Hampton T G, Wang J F, Green P J, Magnuson T, Douglas P S, Morgan J P, Neel B G

Abstract excerpt

Atrioventricular and semilunar valve abnormalities are common birth defects, but how cardiac valvulogenesis is directed remains largely unknown. During studies of genetic interaction between Egfr, encoding the epidermal growth factor receptor, and Ptpn11, encoding the protein-tyrosine-phosphatase Shp2, we discovered that Egfr is required for semilunar, but not atrioventricular, valve development. Although...

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PMID: 10700187
DOI: 10.1038/73528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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