Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.

doi:10.1021/jm040849g

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Article

Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.

Journal of medicinal chemistry - 10 Mar 2005

Matsoukas John, Apostolopoulos Vasso, Kalbacher Hubert, Papini Anna-Maria, Tselios Theodore, Chatzantoni Kokona, Biagioli Tiziana, Lolli Francesco, Deraos Spyros, Papathanassopoulos Panagiotis, Troganis Anastassios, Mantzourani Efthimia, Mavromoustakos Thomas, Mouzaki Athanasia

Abstract excerpt

A cyclic analogue, [cyclo(87-99)MBP(87)(-)(99)], of the human immunodominant MBP(87)(-)(99) epitope, was designed based on ROESY/NMR distance information and modeling data for linear epitope 87-99, taking into account T-cell (Phe(89), Lys(91), Pro(96)) and HLA (His(88), Phe(90), Ile(93)) contact side-chain information. The cyclic analogue was found to induce experimental allergic encephalomyelitis (EAE), to bind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15743189
DOI: 10.1021/jm040849g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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