Article
Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope.
Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006
Musse Abdiwahab A, Boggs Joan M, Harauz George
Abstract excerpt
The degradation of myelin in the CNS is the hallmark of multiple sclerosis. Reduction in the net positive charge of myelin basic protein (MBP), through deimination, correlates strongly with disease severity and may mediate myelin instability and loss of compaction. Using Cys scanning, spin labeling, EPR spectroscopy, and site-specific proteolysis, we show that in the membrane-bound state the primary...
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