Article
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2008
Agell Laia, Hernández Silvia, de Muga Silvia, Lorente José A, Juanpere Núria, Esgueva Raquel, Serrano Sergi, Gelabert Antoni, Lloreta Josep
Abstract excerpt
Krüppel-like factor 6 (KLF6) has been reported to act as a tumor suppressor gene involved in the regulation of the cell cycle by activating p21 in a p53-independent manner. Many studies suggest that KLF6 is inactivated by allelic loss and somatic mutation. However, there is a high variability in the reported frequency of mutations (from 1 to 55%). TP53 also regulates the cell cycle through the activation of p21....
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