Article
No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).
The Journal of surgical research - 1 Mar 2005
Martin Robert C G, Lan Qing, Hughes Kalista, Doll Mark A, Martini Benjamin D, Lissowska Jolanta, Zatonski Witold, Rothman Nathaniel, Hein David W
Abstract excerpt
BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress. A genetic polymorphism in the mitochondrial targeting sequence of this gene has been associated with increased cancer risk. This one base pair transition (-9 T>C) leads to a Val to Ala...
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