Article
Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques.
Vaccine - 14 Mar 2005
De Rose Robert, Chea Socheata, Dale C Jane, Reece Jeanette, Fernandez Caroline S, Wilson Kim M, Thomson Scott, Ramshaw Ian A, Coupar Barbara E H, Boyle David B, Sullivan Mark T, Kent Stephen J
Abstract excerpt
To induce broad T cell immunity to HIV-1, we evaluated the safety, immunogenicity and dose-response relationship of DNA and recombinant Fowlpoxvirus (rFPV) vaccines encoding five shared HIV subtype AE genes (Gag, Pol, Env, Tat, Rev) in pigtail macaques. The DNA (three doses of either 1 mg or 4.5 mg) and rFPV (a single boost of either 5 x 10(7) or 2 x 10(8) plaque forming units) vaccines were administered...
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