Article
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.
Annals of the rheumatic diseases - 1 Sept 2005
Barton A, Bowes J, Eyre S, Symmons D, Worthington J, Silman A
Abstract excerpt
BACKGROUND: A functional haplotype of the peptidylarginine deiminase 4 (PADI4) gene has recently been identified as a rheumatoid arthritis susceptibility gene in a Japanese but not in a UK population. One possible explanation for this disparity is that the gene determines severity of rather than susceptibility to inflammatory polyarthritis (IP) and that the UK and Japanese cohorts differed in terms of outcome....
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