Article
Altered gingipain maturation in vimA- and vimE-defective isogenic mutants of Porphyromonas gingivalis.
Infection and immunity - 1 Mar 2005
Vanterpool Elaine, Roy Francis, Sandberg Lawrence, Fletcher Hansel M
Abstract excerpt
We have previously shown that gingipain activity in Porphyromonas gingivalis is modulated by the unique vimA and vimE genes. To determine if these genes had a similar phenotypic effect on protease maturation and activation, isogenic mutants defective in those genes were further characterized. Western blot analyses with antigingipain antibodies showed RgpA-, RgpB-, and Kgp-immunoreactive bands in membrane...
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