Article
[Heteroplasmy: a common phenomenon of mitochondrial genome mutations in human tumor tissues].
Yi chuan = Hereditas - 1 Jan 2005
Tan Duan-Jun, Liu Ling-Ling, Wen Yi, Liu Peng, Liu Peng, Chang Julia, Yeh Kun-Tu
Abstract excerpt
To explore the status of heteroplasmy and homoplasmy of Mitochondrial DNA somatic mutations in different tumors. DNA from 149 tumors and corresponding normal tissues were extracted and entire mitochondrial genome was amplified using 32 pairs of overlapping primers. The somatic mutations were screened by temporal temperature gradient gel electrophoresis and their heteroplasmic statute were identified by...
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