Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidemiologic studies of folate and colorectal neoplasia: a review.

The Journal of nutrition - 1 Aug 2002

Giovannucci Edward

Abstract excerpt

Dietary folate influences DNA methylation, synthesis and repair. Aberrations in these DNA processes may enhance carcinogenesis, particularly in rapidly proliferative tissues such as the colorectal mucosa. DNA methylation abnormalities may influence the expression of cancer-related genes, and inadequate levels of folate may lead to uracil misincorporation into DNA and to chromosomal breaks. Folate deficiency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Diet
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid Deficiency

Share to Genetic Predisposition to Disease

Share to Methionine

Share to Risk Factors

Source

Identifiers

PMID: 12163691
DOI: 10.1093/jn/132.8.2350S

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidemiologic studies of folate and colorectal neoplasia: a review.PMID 12163691Read ↗

Folate, colorectal cancer and the involvement of DNA methylationSemantic proximity Read ↗

Folate, colorectal carcinogenesis, and DNA methylation: Lessons from animal studiesSemantic proximity Read ↗

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesisSemantic proximity Read ↗

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.Semantic proximity Read ↗

Folate and DNA Methylation: A Mechanistic Link between Folate Deficiency and Colorectal Cancer?Semantic proximity Read ↗

[Colorectal cancer and folate].Semantic proximity Read ↗

Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.Semantic proximity Read ↗

Folate, Methionine, and Alcohol Intake and Risk of Colorectal AdenomaSemantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

Nutrigenetics in cancer research--folate metabolism and colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.