Article
P16/MTS1 and pRB expression in endometrial carcinomas.
Virchows Archiv : an international journal of pathology - 1 Jan 1999
Milde-Langosch K, Riethdorf L, Bamberger A M, Löning T
Abstract excerpt
p16MTS1/CDKN1 and the retinoblastoma protein Rb are both involved in negative regulation of G1/S progression in the mammalian cell cycle. Inactivation of one of these tumour suppressor genes is involved in many malignant tumours, and in some studies a negative correlation of p16 and Rb expression has been found. In order to study this interaction in endometrial carcinogenesis, we investigated 36 endometrial...
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