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Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

5 Sept 2018

Abstract excerpt

T cells play a crucial role in viral clearance and vaccine responses; however, the mechanisms that regulate their homeostasis during viral infections remain unclear. In this study, we investigated the machineries of T-cell homeostasis and telomeric DNA damage using a human model of hepatitis C virus (HCV) infection. We found that naïve CD4 T cells in chronically HCV-infected patients (HCV T cells) were...

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Share to Cytomegalovirus and herpesvirus research
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 30185784
DOI: 10.1038/s41419-018-0897-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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