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Article

Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association.

Psychiatric genetics - 1 Mar 2005

Nievergelt Caroline M, Kripke Daniel F, Remick Ronald A, Sadovnick A Dessa, McElroy Susan L, Keck Paul E, Kelsoe John R

Abstract excerpt

Bipolar disorder is associated with malfunctions of the circadian system, which regulates individual circadian rhythms and which enables the adaptation to a daily 24-h cycle and seasonal change. One of the human circadian clock genes, cryptochrome 1 (Cry1) (located on 12q23-q24.1) was analyzed because of its close correspondence to a linkage hotspot for bipolar disorder. We found no evidence for linkage of 52...

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PMID: 15722957
DOI: 10.1097/00041444-200503000-00008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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