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Article

PI3K inhibition potentiates Bcl‐2‐dependent apoptosis in renal carcinoma cells

7 Feb 2013

Abstract excerpt

Inhibitors of PI3-K/Akt are currently being assessed clinically in patients with advanced RCC. Identification of therapeutic strategies that might enhance the efficacy of PI3-K/Akt inhibitors is therefore of great interest. As PI3-K inhibition would be expected to have many pro-apoptotic effects, we hypothesized that there may be unique synergy between PI3-K inhibitors and BH3-mimetics. Towards this end, we...

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PMID: 23387989
DOI: 10.1111/jcmm.12019

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