Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2003

Ceelie H, Spaargaren-Van Riel C C, De Jong M, Bertina R M, Vos H L

Abstract excerpt

BACKGROUND: Prothrombin is a key component in blood coagulation. Overexpression of prothrombin leads to an increased risk of venous thrombosis. Therefore, the study of the transcriptional regulation of the prothrombin gene may help to identify mechanisms of overexpression. OBJECTIVES: The aim of our study was to localize the regions within the prothrombin enhancer responsible for its activity, to identify the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Databases as Topic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 1

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Hepatocyte Nuclear Factor 1-beta

Share to Hepatocyte Nuclear Factor 3-beta

Share to Hepatocyte Nuclear Factor 4

Share to Sp3 Transcription Factor

Source

Identifiers

PMID: 12911579
DOI: 10.1046/j.1538-7836.2003.00393.x

Genes

FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.PMID 12911579Read ↗

Functional Characterization of the Human Factor VII 5′-Flanking RegionSemantic proximity Read ↗

cis-Acting Elements and Transcription Factors Involved in the Promoter Activity of the Human Factor VIII GeneSemantic proximity Read ↗

Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.Semantic proximity Read ↗

Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors.Semantic proximity Read ↗

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.Semantic proximity Read ↗

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional ActivationSemantic proximity Read ↗

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.Semantic proximity Read ↗

A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription FactorsSemantic proximity Read ↗

Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene ExpressionSemantic proximity Read ↗

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease.Semantic proximity Read ↗

Characterization of the human protein S gene promoter: a possible role of transcription factors Sp1 and HNF3 in liver.Semantic proximity Read ↗

Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β PathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.