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Article

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2003

Ceelie H, Spaargaren-Van Riel C C, De Jong M, Bertina R M, Vos H L

Abstract excerpt

BACKGROUND: Prothrombin is a key component in blood coagulation. Overexpression of prothrombin leads to an increased risk of venous thrombosis. Therefore, the study of the transcriptional regulation of the prothrombin gene may help to identify mechanisms of overexpression. OBJECTIVES: The aim of...

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Source

Identifiers

PMID: 12911579
DOI: 10.1046/j.1538-7836.2003.00393.x

Genes

FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12911579-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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