Article
Complete nucleotide sequence of the antithrombin gene: evidence for homologous recombination causing thrombophilia.
Biochemistry - 27 Apr 1993
Olds R J, Lane D A, Chowdhury V, De Stefano V, Leone G, Thein S L
Abstract excerpt
Antithrombin is the principle regulator of thrombin and other blood coagulation proteinases. It is a member of the serpin family of proteinase inhibitors. The genomic sequence of the antithrombin locus has been completed, revealing a gene spanning 13,477 base pairs from the transcription start si...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Antithrombins
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA
- Humans
- Introns
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping
- Thrombosis